Sustanon is actually the trade name for a mixture (also referred to as a blend) of 4 different ester variants of Testosterone. The exact blend of Testosterone esters in the Sustanon 250 blend is as follows:
30mg Testosterone Propionate
60mg Testosterone Phenylpropionate
60mg Testosterone Isocaproate
100mg Testosterone Decanoate
The basis for combining these esters is for the purpose of creating a Testosterone drug that can provide the patient with the benefits of both a fast acting Testosterone into the bloodstream along with a slower release in order to achieve peak blood plasma levels quicker and keep them sustained for much longer than traditional single esters.
The aromatase enzyme, which is responsible for aromatization (or conversion) of Testosterone into Estrogen. Estrogenic side effects of Sustanon include water retention and bloating, high blood pressure (water retention), increased possible fat retention/gain, and gynecomastia. These are all dose dependent, and at higher dosages Sustanon will increase the possibility, frequency and severity of these side effects. The use of an aromatase inhibitor and/or an Estrogen blocker, like Nolvadex (Tamoxifen Citrate), Arimidex (Anastrozole), Femara (Letrozole), Aromasin (Exemestane) or Proviron (Mesterolone) is necessary.
Androgenic side effects are also cause for concern as Testosterone will readily convert into Dihydrotestosterone (DHT) in various tissues throughout the body. DHT causes an increase in androgenic side effects and is a much more powerful androgen. These side effects include: increased acne and oily skin (sebum secretion), body and facial hair growth, and the increased risk of Male Pattern Baldness (MPB) in individuals that are predisposed to it. These Sustanon side effects can be controlled with the use of 5-alpha reductase inhibitors such as Propecia.
Hepatotoxicity and liver issues are not a concern with the use of Sustanon 250 or any injectable Testosterone. Testosterone promotes a low/moderate reduction in HDL “good’ cholesterol”.
Testosterone will suppress and shutdown of endogenous Testosterone production, especially at super-physiological dosages used by most athletes.
For Testosterone replacement therapy (TRT), Sustanon dosages average at 250mg administration every 3 weeks. For most beginners in bodybuilding circles, Sustanon dosages start at around 250 – 500mg weekly. Intermediate users often utilize about of 500 – 750mg per week but will often keep dosages in the 500mg weekly range when utilizing other anabolic compounds with it such as Deca-Durabolin (Nandrolone Decanoate) or Equipoise (Boldenone Undecylenate) etc. Advanced users are renowned to go as high as 750 – 1000mg per week in combination with other anabolic compounds mentioned above.